Anthony Greenberg ~ Postdoctoral Associate

101 Biotechnology Building
Ithaca, NY 14853

Email: ajg67 at cornell dot edu

Research Interests:
I use quantitative, population and molecular genetics to study fundamental biological processes at the level of whole systems. My current interest is in understanding how naturally occurring mutations, both adaptive and deleterious, affect organismal phenotypes and hence evolutionary trajectories of species, using the metabolic network of Drosophila melanogaster as a model system. My general approach is to combine rigorous experiments with sophisticated computational tools. I have developed multivariate Bayesian models to estimate quantitative-genetic parameters and am working to extend these models to genome-wide association studies. I am also developing efficient experimental methods to test predictions generated from these models.

  • Greenberg, A. J., S. R. Hackett, L. G. Harshman and A. G. Clark (2011). Quantitative-genetic analysis of the energy metabolism regulatory network in Drosophila. In review.
  • He Z, Zhai W, Wen H, Tang T, Wang Y, Lu X, Greenberg AJ, Hudson RR, Wu CI, Shi S. 2011. Two evolutionary histories in the genome of rice: the roles of domestication genes. Link
  • Lu X, Shapiro JA, Ting CT, Li Y, Li C, Xu J, Huang H, Cheng YJ, Greenberg AJ, Li SH, Wu ML, Shen Y, Wu CI. 2010. Genome-wide misexpression of X-linked versus autosomal genes associated with hybrid male sterility. Link
  • Greenberg AJ, Hackett SR, Harshman LG, Clark AG. 2010. A hierarchical Bayesian model for a novel sparse partial diallel crossing design. Link
  • Greenberg AJ, Stockwell SR, Clark AG. 2008. Evolutionary constraint and adaptation in the metabolic network of Drosophila. Link
  • Larracuente AM, Sackton TB, Greenberg AJ, Wong A, Singh ND, Sturgill D, Zhang Y, Oliver B, Clark AG. 2008. Evolution of protein-coding genes in Drosophila. Link
  • Drosophila 12 Genomes Consortium. 2007. Evolution of genes and genomes on the Drosophila phylogeny. Link
  • Greenberg AJ, Moran JR, Wu CI. 2006. Proper control of genetic background with precise allele substitution: a comment on Coyne and Elwyn. Link
  • Greenberg AJ, Wu CI; SMBE Tri-National Young Investigators. 2006. Proceedings of the SMBE Tri-National Young Investigators' Workshop 2005. Molecular genetics of natural populations. Link
  • Greenberg AJ, Moran JR, Fang S, Wu CI. 2006. Adaptive loss of an old duplicated gene during incipient speciation. Link
  • Greenberg AJ, Yanowitz JL, Schedl P. 2004. The Drosophila GAGA factor is required for dosage compensation in males and for the formation of the male-specific-lethal complex chromatin entry site at 12DE. Link
  • Greenberg AJ, Moran JR, Coyne JA, Wu CI. 2003. Ecological adaptation during incipient speciation revealed by precise gene replacement. Link
  • Greenberg AJ, Schedl P. 2001. GAGA factor isoforms have distinct but overlapping functions in vivo. Link