The Mezey group is focused on understanding the genetics, development, and evolution
of complex phenotypes. Research in our group occurs in two major divisions:
- development of computational inference approaches for mapping loci and modeling pathways,
- experimental quantitative analysis of genetic pathways in Drosophila.
For the first of these, we are developing
approaches that we apply to a wide variety of model organisms including yeast, flies, and humans; the second
is our attempt to develop a quantitative understanding of specific pathways in a genetic model system. These
are complimentary endeavors and members of the group tend to span these divisions. Current research of group
members includes: development of Bayesian approaches for pedigree inference, Bayesian mixture prior approaches for
identifying pathway relationships underlying gene expression variation, analysis of regulation in Drosophila
reproductive genes, and experimental analysis of signal transduction pathways in Drosophila wing development.